LibSearch: A window-based frontend to remote bIbliographic databases on the internet

Over the past several years, a number of wide-area information navigation and discovery tools have been introduced, including WAIS[1], Gopher[2], World-Wide Web[3], etc. In this paper, we describe a graphical query interface to remote bibliographic databases that can be found on the internet. A library query client, called LibSearch, has been designed and implemented using a set of APIs based on Z39.50 protocol standard[4]. Z39.50 is an application-layer protocol within the OSI reference model designed to allow library users to remotely access the bibliographic records in the library systems. As increasing number of OPAC systems are being established as Z39.50 servers on the internet, Libsearch provides a user-friendly environment to specify search requests and retrieve bibliographic information from these servers. LibSearch supports: (1) the use of window icons to enable users to easily carry out their search activities, (2) remote accesses to diverse library catalogue system..

Improving skills in rounding off the whole number

This study was conducted to address teaching and learning skills in rounding off a whole number. This study consisted of 15 years 4 students from the Kong Nan Chinese Primary School, Parit Raja, Johor, Malaysia. Initial survey to identify this problem was carried out by analyzing the exercise books and exercises in pre-test. Based on these analyses, a large number of students were not proficient in relevant skills. A ‘q’ technique was introduced as an approach in teaching and learning to help students master the skills of rounding whole numbers. In summary, this technique helps students to remember the sequence of processes and process in rounding numbers. A total of four sessions of teaching and learning activities that take less than an hour have been implemented specifically to help students to master this technique. Results of the implementation of these activities have shown very positive results among the students. Two post tests were carried out to see the effectiveness of techniques and the results shows that 100% of students were able to answer correctly at least three questions correctly. The t-test analysis was clearly showed the effectiveness of ‘q’ technique. This technique also indirectly helps to maintain and increase student interest in learning Mathematics. This is shown with the active involvement of students in answering questions given by the teacher

Investigating the influence of offline friendship on Twitter networking behaviors

Singapore National Research Foundation under its International Research Centre @ Singapore Funding Initiativ

G-portal : A map-based digital library for distributed geospatial and georeferenced resources

SingAREN Projec

Germline breast cancer susceptibility genes, tumor characteristics, and survival.

BACKGROUND: Mutations in certain genes are known to increase breast cancer risk. We study the relevance of rare protein-truncating variants (PTVs) that may result in loss-of-function in breast cancer susceptibility genes on tumor characteristics and survival in 8852 breast cancer patients of Asian descent. METHODS: Gene panel sequencing was performed for 34 known or suspected breast cancer predisposition genes, of which nine genes (ATM, BRCA1, BRCA2, CHEK2, PALB2, BARD1, RAD51C, RAD51D, and TP53) were associated with breast cancer risk. Associations between PTV carriership in one or more genes and tumor characteristics were examined using multinomial logistic regression. Ten-year overall survival was estimated using Cox regression models in 6477 breast cancer patients after excluding older patients (≥75years) and stage 0 and IV disease. RESULTS: PTV9genes carriership (n = 690) was significantly associated (p < 0.001) with more aggressive tumor characteristics including high grade (poorly vs well-differentiated, odds ratio [95% confidence interval] 3.48 [2.35-5.17], moderately vs well-differentiated 2.33 [1.56-3.49]), as well as luminal B [HER-] and triple-negative subtypes (vs luminal A 2.15 [1.58-2.92] and 2.85 [2.17-3.73], respectively), adjusted for age at diagnosis, study, and ethnicity. Associations with grade and luminal B [HER2-] subtype remained significant after excluding BRCA1/2 carriers. PTV25genes carriership (n = 289, excluding carriers of the nine genes associated with breast cancer) was not associated with tumor characteristics. However, PTV25genes carriership, but not PTV9genes carriership, was suggested to be associated with worse 10-year overall survival (hazard ratio [CI] 1.63 [1.16-2.28]). CONCLUSIONS: PTV9genes carriership is associated with more aggressive tumors. Variants in other genes might be associated with the survival of breast cancer patients. The finding that PTV carriership is not just associated with higher breast cancer risk, but also more severe and fatal forms of the disease, suggests that genetic testing has the potential to provide additional health information and help healthy individuals make screening decisions

RAFT dispersion polymerization : a method to tune the morphology of thymine-containing self-assemblies

YesThe synthesis and self-assembly of thymine-containing polymers were performed using RAFT dispersion polymerization. A combination of microscopy and scattering techniques was used to analyze the resultant complex morphologies. The primary observation from this study is that the obtained aggregates induced during the polymerization were well-defined despite the constituent copolymers possessing broad dispersities. Moreover, a variety of parameters, including the choice of polymerization solvent, the degree of polymerization of both blocks and the presence of an adenine-containing mediator, were observed to affect the resultant size and shape of the assembly.University of Warwick, National Science Foundation (U.S.) (NSF), Engineering and Physical Sciences Research Council (EPSRC

Genetic Associations of Type 2 Diabetes with Islet Amyloid Polypeptide Processing and Degrading Pathways in Asian Populations

10.1371/journal.pone.0062378PLoS ONE86

The genetic architecture of type 2 diabetes

The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms